Bening paraxysmal torticollis is a sensoriomotos trigeminocervical convergence merchanisms? Experimental evidence.
DOI:
https://doi.org/10.48208/HeadacheMed.2021.52Palavras-chave:
benign paroxysmal torticollis, precursors of migraine, sensorio motor, trigeminocervical convergenceResumo
Introduction
Benign paroxysmal torticollis (BPT) is likely an age-sensitive, childhood periodic syndromes that are commonly precursors of migraine, with atypical postural behavior (torticollis) to start early and self-limited, which of unknown etiology.
Objective
To prove the existence of forms of sensorimotor convergence between the trigeminal nerve and upper cervical roots respectively.
Methods
Ninety-five rats Norvegicus were submitted to infraorbital nerve blockade using botulinum neurotoxin type A (BoNT/A) (n=48) controlled by isotonic saline solution animals (ISS) (n=47). After 84 days the animals were evaluated on their motor functions using open field test and postural behavior.
Results
Of the 48 animals in the BoNT/A group one animal showed the torticollis ipsilateral to BoNT/A injection. The macroscopic analysis showed fasciculations on clavotrapezius muscle. The biopsy with optical and electronic microscopy of this muscle showed changes suggestive of denervation secondary to BoNT/A.
Conclusion
We suggested the existence of a pathway sensoriomotor probably in the brainstem involves the trigeminal system and cervical motoneurons.
Downloads
Referências
Drigo P, Carli G and Laverda AM. Benign paroxysmal torticollis of infancy. Brain Dev 2000;22(3):169-172 Doi:10.1016/s0387-7604(00)00099-1 DOI: https://doi.org/10.1016/S0387-7604(00)00099-1
Piovesan EJ, Kowacs PA, Tatsui CE, Lange MC, Ribas LC and Werneck LC. Referred pain after painful stimulation of the greater occipital nerve in humans: evidence of convergence of cervical afferences on trigeminal nuclei. Cephalalgia 2001;21(2):107-109 Doi:10.1046/j.1468-2982.2001.00166.x DOI: https://doi.org/10.1046/j.1468-2982.2001.00166.x
Piovesan EJ, Werneck LC, Kowacs PA, Tatsui CE, Lange MC and Vincent M. Anesthetic blockade of the greater occipital nerve in migraine prophylaxis. Arq Neuropsiquiatr 2001;59(3-a):545-551 DOI: https://doi.org/10.1590/S0004-282X2001000400012
Piovesan EJ, Di Stani F, Kowacs PA, Mulinari RA, Radunz VH, Utiumi M, . . . Werneck LC. Massaging over the greater occipital nerve reduces the intensity of migraine attacks: evidence for inhibitory trigemino-cervical convergence mechanisms. Arq Neuropsiquiatr 2007;65(3a):599-604 Doi:10.1590/s0004-282x2007000400010 DOI: https://doi.org/10.1590/S0004-282X2007000400010
Saper JR, Dodick DW, Silberstein SD, McCarville S, Sun M and Goadsby PJ. Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study. Cephalalgia 2011;31(3):271-285 Doi:10.1177/0333102410381142 DOI: https://doi.org/10.1177/0333102410381142
Calhoun AH, Ford S, Millen C, Finkel AG, Truong Y and Nie Y. The prevalence of neck pain in migraine. Headache 2010;50(8):1273-1277 Doi:10.1111/j.1526-4610.2009.01608.x DOI: https://doi.org/10.1111/j.1526-4610.2009.01608.x
Piovesan EJ, Kowacs PA and Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep 2003;7(5):377-383 Doi:10.1007/s11916-003-0037-x DOI: https://doi.org/10.1007/s11916-003-0037-x
Kitamura S and Sakai A. A study on the localization of the sternocleidomastoid and trapezius motoneurons in the rat by means of the HRP method. Anat Rec 1982;202(4):527-536 Doi:10.1002/ar.1092020412 DOI: https://doi.org/10.1002/ar.1092020412
Snyder CH. Paroxysmal torticollis in infancy. A possible form of labyrinthitis. Am J Dis Child 1969;117(4):458-460 Doi:10.1001/archpedi.1969.02100030460013 DOI: https://doi.org/10.1001/archpedi.1969.02100030460013
Deonna T and Martin D. Benign paroxysmal torticollis in infancy. Arch Dis Child 1981;56(12):956-959 Doi:10.1136/adc.56.12.956 DOI: https://doi.org/10.1136/adc.56.12.956
Sanner G and Bergström B. Benign paroxysmal torticollis in infancy. Acta Paediatr Scand 1979;68(2):219-223 Doi:10.1111/j.1651-2227.1979.tb04992.x DOI: https://doi.org/10.1111/j.1651-2227.1979.tb04992.x
Dunn DW and Snyder CH. Benign paroxysmal vertigo of childhood. Am J Dis Child 1976;130(10):1099-1100 Doi:10.1001/archpedi.1976.02120110061008 DOI: https://doi.org/10.1001/archpedi.1976.02120110061008
Deonna T. Neurologic problems of abdominal migraine in children. Clinical study of 15 cases and review of the literature. Pediatrie 1977;32(2):119-127
Giffin NJ, Benton S and Goadsby PJ. Benign paroxysmal torticollis of infancy: four new cases and linkage to CACNA1A mutation. Dev Med Child Neurol 2002;44(7):490-493 Doi:10.1017/s0012162201002407 DOI: https://doi.org/10.1111/j.1469-8749.2002.tb00311.x
Rosman NP, Douglass LM, Sharif UM and Paolini J. The neurology of benign paroxysmal torticollis of infancy: report of 10 new cases and review of the literature. J Child Neurol 2009;24(2):155-160 Doi:10.1177/0883073808322338 DOI: https://doi.org/10.1177/0883073808322338
Cuvellier JC, Mars A and Vallée L. The prevalence of premonitory symptoms in paediatric migraine: a questionnaire study in 103 children and adolescents. Cephalalgia 2009;29(11):1197-1201 Doi:10.1111/j.1468-2982.2009.01854.x DOI: https://doi.org/10.1111/j.1468-2982.2009.01854.x
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Elcio Juliato Piovesan, Pedro Andre Kowacs
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
