Topiramate and cognitive function: review

Authors

  • Karllus Andhre Leite de Mendonça Santos Universidade Federal de Pernambuco
  • Hugo André de Lima Martins Universidade Federal de Pernambuco
  • Valdenilson Ribeiro Ribas Universidade Federal de Pernambuco
  • Louana Cassiano Silva Lima Universidade Federal de Pernambuco
  • Camila Cordeiro dos Santos Universidade Federal de Pernambuco
  • Daniella de Araújo Oliveira Universidade Federal de Pernambuco
  • Marcelo Moraes Valença Universidade Federal de Pernambuco

DOI:

https://doi.org/10.48208/HeadacheMed.2015.3

Keywords:

Cognition, Epilepsy, Migraine, Obesity, Psychiatric, Topiramate

Abstract

Despite the therapeutic efficacy, in its various indications, cognitive side effects are common findings with topiramate. Descriptive studies indicate nonspecific complaints cognitive, psychomotor slowness and language difficulties, as main complaints among patients who had to discontinue use of the medication, even when it shows efficacy in symptomatic control of the patient. Even in patients who do not have cognitive complaints topiramate-related, changes were found in the performance of psychometric tests. The negative cognitive effects induced by topiramate are often temporary and cease after its discontinuation. There appears to be certain conditions associated with an increased risk for the development of side effects such as titration scheme, the dose used, maintenance time polytherapy and individual susceptibility. The mechanism in which topiramate leads to cognitive impairments is still poorly understood. Neurophysiology and functional neuroimaging studies seeking to elucidate the question. The magnitude of the cognitive changes may be enough to interfere with school performance, work and social relationships and are among the leading causes of discontinuation of medication during treatment.

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Author Biographies

Karllus Andhre Leite de Mendonça Santos, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Hugo André de Lima Martins, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Valdenilson Ribeiro Ribas, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Louana Cassiano Silva Lima, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Camila Cordeiro dos Santos, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Daniella de Araújo Oliveira, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

Marcelo Moraes Valença, Universidade Federal de Pernambuco

Unidade Funcional de Neurologia e Neurocirurgia, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brasil

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Published

31/03/2015

How to Cite

1.
Santos KAL de M, Martins HA de L, Ribas VR, Lima LCS, Santos CC dos, Oliveira D de A, Valença MM. Topiramate and cognitive function: review. HM [Internet]. 2015 Mar. 31 [cited 2021 Dec. 2];6(1):12-8. Available from: https://headachemedicine.com.br/index.php/hm/article/view/402

Issue

Section

Review

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