The role of TRPM8 in the pathophysiology of migraine
DOI:
https://doi.org/10.48208/HeadacheMed.2020.17Palavras-chave:
TRPM Cation Channels, Migraine Disorders, HyperalgesiaResumo
The Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the mammal TRPM subfamily. TRPM8 is involved in menthol-induced cold allodynia, a condition that activates the left lateral thalamus and the primary and secondary somatosensory cortices, which are related to pain processing. Cold is a well-known trigger of migraine. Thirty-nine articles were identified, 27 of which were selected for review after reading the abstracts. Fourteen papers were further excluded. TRPM8 seems to be involved in the pain mechanism of migraine and therefore should be considered as a target for the development of therapies against this type of primary headache.
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2020-09-30
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Nogueira E de AG, Fragoso YD. The role of TRPM8 in the pathophysiology of migraine. Headache Med [Internet]. 30º de setembro de 2020 [citado 21º de novembro de 2024];11(3):57-60. Disponível em: https://headachemedicine.com.br/index.php/hm/article/view/329
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Copyright (c) 2020 Headache Medicine
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
