Efeito do óleo essencial de hortelã-pimenta (Mentha piperita L.) nas respostas semelhantes às da enxaqueca em ratas
DOI:
https://doi.org/10.48208/HeadacheMed.2024.17Palavras-chave:
Peptídeo relacionado ao gene da calcitonina, Alodinia cutânea, Fotossensibilidade, Mentol, InalaçãoResumo
A enxaqueca é um distúrbio neurológico grave e incapacitante caracterizado por cefaleia, fotofobia, fonofobia, náuseas e vômitos. É considerada a principal causa de incapacidade entre 15 e 49 anos, sendo duas a três vezes mais frequente no sexo feminino. O tratamento farmacológico da enxaqueca avançou nos últimos anos, mas ainda é considerado insatisfatório para um número significativo de pacientes. Existem evidências de que os óleos essenciais podem trazer benefícios no tratamento da enxaqueca. Neste estudo, foi testada a hipótese de que o óleo essencial de hortelã-pimenta (Mentha piperita L.) poderia reduzir as respostas relacionadas à enxaqueca em ratas. O modelo consistiu na injeção de peptídeo relacionado ao gene da calcitonina (CGRP) no gânglio do trigêmeo (TG) de ratas para induzir o desenvolvimento de alodinia cutânea periorbital imediata e fotossensibilidade tardia (24 horas após o CGRP). A inalação do óleo essencial de hortelã-pimenta durante 15 minutos antes da injeção de CGRP não reduziu a alodinia periorbital e a fotossensibilidade das ratas. No entanto, quando a exposição ocorreu após a injeção de CGRP, o óleo essencial de hortelã-pimenta causou uma redução significativa em ambos os parâmetros. Da mesma forma, a aplicação intranasal de mentol causou uma redução significativa da alodinia periorbital induzida pelo CGRP. Em conclusão, o óleo essencial de hortelã-pimenta e o mentol podem representar uma terapia abortiva adjuvante, segura, de baixo custo e não invasiva para o controle das crises. No entanto, estudos clínicos de boa qualidade são necessários para determinar eficácia, segurança e estabelecer o melhor regime de tratamento.
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Copyright (c) 2024 Laura de Oliveira Koren, Vanessa Bordenowsky Pereira Lejeune, Darciane Favero Baggio, Fernanda Mariano Ribeiro da Luz, Juliana Geremias Chichorro (Author)
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Grant numbers 001 -
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Grant numbers 303781/2020-3
