O Papel do Sistema Imune na Fisiopatologia da Migrânea
DOI:
https://doi.org/10.48208/HeadacheMed.2024.14Palavras-chave:
migrânea, cefaleia, sistema imune, inflamaçãoResumo
A migrânea é uma doença caracterizada por episódios repetidos de cefaleia que são mediados pela ativação trigeminal e liberação do peptídeo CGRP. Adicionalmente existe uma complexa interação com o sistema imune através da inflamação neurogênica e neuroinflamação, com um desequilíbrio entre a resposta pró-inflamatória e a resposta regulatória. O sistema imune inato atua na migrânea principalmente por meio do aumento das citocinas pró-inflamatórias, com destaque para IL-1β cuja produção pode ocorrer no complexo córtex-meninge em decorrência da depressão cortical alastrante ou no gânglio trigeminal sensibilizado pelo CGRP. Algumas evidências sugerem também efeito do sistema imune adaptativo Th1 e principalmente Th2 que culmina com a ativação de mastócitos meníngeos. Por outro lado, células T regulatórias estão quantitativamente diminuídas na migrânea e acontecem oscilações dos níveis de IL-10, principal citocina anti-inflamatória. Existem evidências da atuação do sistema imune na migrânea, no entanto seu efeito ainda é pouco conhecido, com necessidade de investigação adicional.
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Copyright (c) 2024 Aline Vitali da Silva, Valéria Aparecida Bello, Regina Célia Poli Frederico, Carlos Eduardo Coral de Oliveira, Adriano Torres Antonucci, Edna Maria Vissoci Reiche, Andréa Name Colado Simão (Author)
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