Melatonin reverts CGRP expression induced by capsaicin

Authors

  • Fabiano da Cunha Tanuri
  • Debora Amado
  • Eliangela de Lima
  • Iron Dangoni Filho
  • Mario Fernando Prieto Peres

DOI:

https://doi.org/10.48208/HeadacheMed.2019.6

Keywords:

Melatonin, CGRP, Animal Model

Abstract

Introduction: CGRP, a neuropeptide synthetized and released in the central nervous system and potent vasodilator, has been implicated in migraine physiopathology. Because of that, there are CGRP targeted therapies that decrease CGRP levels. Melatonin, a pineal gland secretion, has already proved its analgesic effect. We aimed to study CGRP expression in an animal model comparing capsaicin, CGRP and melatonin. Methods: We used in our study male animal rats and separated them into groups based in the kind of received solution (control group, capsaicin only and melatonin plus capsaicin). It was prepared brain stem slices and measured the CGRP levels in the trigemino nucleus caudalis (TNC). Results: Capsaicin group (N = 5) presented low intensity of GCRP expression and animals that received capsaicin plus melatonin (N = 5) showed high intensity of CGRP expression compared to capsaicin group. Conclusion: Melatonin decreases CGRP in an experimental model in rats induced by capsaicin, reducing its inflammatory action in cerebral vessels. 

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Author Biographies

Fabiano da Cunha Tanuri

Departamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

Debora Amado

Departamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

Eliangela de Lima

Departamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil

Iron Dangoni Filho

Hospital Israelita Albert Einstein, São Paulo, Brazil

Mario Fernando Prieto Peres

Hospital Israelita Albert Einstein, São Paulo, Brazil

 Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo

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Published

31/03/2019

How to Cite

1.
Tanuri F da C, Amado D, Lima E de, Dangoni Filho I, Peres MFP. Melatonin reverts CGRP expression induced by capsaicin. HM [Internet]. 2019 Mar. 31 [cited 2022 Aug. 18];10(1):24-8. Available from: https://headachemedicine.com.br/index.php/hm/article/view/62

Issue

Section

Original

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