Lithium-responsive headaches

Abstract

Introduction: Lithium-responsive headaches are primary and they have beginning nocturnal or on awakening. They are classified in three groups: Nocturnal Migraine, Cluster Headache, and Hypnic Headache. All three types show a positive therapeutic response to lithium and the average dose is from 300 to 900 mg at bedtime. Objective: To review the headaches that have nocturnal or on awakening beginnings and those which demonstrate a therapeutic response to lithium. Method: We reviewed the literature on lithium and its historical and pharmacological aspects, and its use in the treatment of nocturnal headaches. Conclusion: Lithium is
an efficient drug in the treatment of nocturnal headache and headache on awakening.