CGRP: from history to clinical application - A review

Authors

  • Afonso Henrique Aragao Instituto de Neurologia de Curitiba, Neurocirurgia,Curitiba, Parana, Brazil
  • Joel Sanabria Duarte Instituto de Neurologia de Curitiba, Neurocirurgia,Curitiba, Parana, Brazil https://orcid.org/0000-0003-1361-7758
  • Daniel Benzecry Almeida Instituto de Neurologia de Curitiba, Neurocirurgia,Curitiba, Parana, Brazil https://orcid.org/0000-0002-9147-3027
  • Ricardo Ramina Instituto de Neurologia de Curitiba, Neurocirurgia,Curitiba, Parana, Brazil

DOI:

https://doi.org/10.48208/HeadacheMed.2020.18

Keywords:

Calcitonin Gene-Related Peptide, Headache, Migraine with aura, Migraine without aura

Abstract

The role of calcitonin gene-related peptide (CGRP) and its receptor have played an important role in migraine for the last decades due to development of therapies that target their receptors at the trigeminal pain system, aiming at prevention or relief of acute migraine attacks. At first, CGRP receptor antagonists, called gepants have demonstrated appropriate effectiveness. In addition, they did not cause vasoconstriction, one of the drawbacks of triptans. However, their use had to be discontinued due to the risk of liver toxicity. Humanized monoclonal antibodies towards CGRP and the CGRP receptor have been developed as an alternative approach to block CGRP transmission. Still, there are some questions not fully answered as where CGRP and its receptor are located, how they influence the mechanisms of migraine attacks and if the blood brain barrier has any sort of importance. There is still much to learn about CGRP and migraine pathophysiology, especially its anatomical target sites and anti-CGRP agents. This paper presents a review of CGRP, including a brief history, focusing in CGRP mechanism, updates and future treatments.

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Published

30/09/2020

How to Cite

1.
Henrique Aragao A, Sanabria Duarte J, Benzecry Almeida D, Ramina R. CGRP: from history to clinical application - A review. HM [Internet]. 2020 Sep. 30 [cited 2021 Sep. 26];11(3):61-7. Available from: https://headachemedicine.com.br/index.php/hm/article/view/304

Issue

Section

Review

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