Petasites hybridus: evidence 1A on migraine prophylaxis
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https://doi.org/10.48208/HeadacheMed.2025.10Palavras-chave:
Headache, Migraine disorders , Petasites , Adult, Plant extractsResumo
Petasites hybridus extract is part of the therapeutic arsenal for migraine prophylaxis. In this commentary, we discuss the study by Lipton et al. (2004), published in Neurology, which presents a high-quality clinical trial demonstrating the efficacy of Petasites hybridus for migraine prevention. The study, conducted by renowned researchers, classifies Petasites hybridus as a Level A treatment (established efficacy based on >2 Class I trials). Despite this strong evidence, questions often arise regarding the appropriate clinical scenarios for prescribing this medication. In addition to analyzing the findings of this seminal study, this commentary explores potential indications for Petasites hybridus in clinical practice.
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Kulinowski Ł, Luca SV, Minceva M, Skalicka-Woźniak K. A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.). J Ethnopharmacol 2022;293:115263. Doi:10.1016/j.jep.2022.115263. DOI: https://doi.org/10.1016/j.jep.2022.115263
Aydın AA, Zerbes V, Parlar H, Letzel T. The medical plant butterbur (Petasites): Analytical and physiological (re)view. J Pharm Biomed Anal 2013;75:220–9. Doi:10.1016/j.jpba.2012.11.028. DOI: https://doi.org/10.1016/j.jpba.2012.11.028
Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED]. Neurology 2012;78:1346–53. Doi:10.1212/WNL.0b013e3182535d0c. DOI: https://doi.org/10.1212/WNL.0b013e3182535d0c
Pringsheim T, Davenport WJ, Mackie G, Worthington I, Aubé M, Christie SN, et al. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci 2012;39:S1-59. DOI: https://doi.org/10.1017/S0317167100015109
Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 2004;63:2240–4. Doi:10.1212/01.WNL.0000147290.68260.11. DOI: https://doi.org/10.1212/01.WNL.0000147290.68260.11
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38:1–211. Doi:10.1177/0333102417738202. DOI: https://doi.org/10.1177/0333102417738202
Grossmann M, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int Journal of Clinical Pharmacology and Therapeutics 2000;38:430–5. Doi:10.5414/CPP38430. DOI: https://doi.org/10.5414/CPP38430
Diener HC, Rahlfs VW, Danesch U. The First Placebo-Controlled Trial of a Special Butterbur Root Extract for the Prevention of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 2004;51:89–97. Doi:10.1159/000076535. DOI: https://doi.org/10.1159/000076535
Borlak J, Diener H-C, Kleeberg-Hartmann J, Messlinger K, Silberstein S. Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review. Front Neurol 2022;13. Doi:10.3389/fneur.2022.864689. DOI: https://doi.org/10.3389/fneur.2022.864689
Rydell CM. American Academy of Neurology (AAN). In: Kreutzer JS, DeLuca J, Caplan B, editors. Encyclopedia of Clinical Neuropsychology, New York, NY: Springer New York; 2011, p. 114–6. Doi:10.1007/978-0-387-79948-3_588. DOI: https://doi.org/10.1007/978-0-387-79948-3_588
Sackett DL, Rosenberg WMC, Gray JAM, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ 1996;312:71–2. Doi:10.1136/bmj.312.7023.71. DOI: https://doi.org/10.1136/bmj.312.7023.71
Crossing the Quality Chasm. Washington, D.C.: National Academies Press; 2001. Doi:10.17226/10027. DOI: https://doi.org/10.17226/10027
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Copyright (c) 2025 Carlos Alberto Bordini (Author)
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
