Evaluation of the use of CGRP monoclonal antibodies (mAbs) in migraine prophylaxis in a private clinic

Authors

DOI:

https://doi.org/10.48208/HeadacheMed.2023.17

Keywords:

Calcitonin gene-related peptide, Migraine, Prophylaxis, Treatment, CGRP monoclonal antibodies

Abstract

Introduction
Migraine is considered the second most prevalent neurological disorder in the population and highly disabling.
Objective
The aim of this study is to evaluate the use of calcitonin gene-related peptide (CGRP) monoclonal antibodies in migraine prophylaxis, with emphasis on therapeutic response, adverse effects, and impacts on quality of life.
Method
A quantitative, retrospective, and descriptive study was carried out, through the analysis of medical records and telephone interviews with patients seen at the Serviço de Neurologia e Neurocirurgia, in the city of Passo Fundo, RGS, Brazil, currently or previously having used at least one dose of the medication.
Conclusion
Thus, it is understood that CGRP monoclonal antibodies are able to reduce monthly headache days, reduce pain intensity and promote improvement in work capacity. Therefore, they can be considered effective, safe and well-adhered medications for migraine prophylaxis.

Downloads

Download data is not yet available.

References

Lombard L, Farrar M, Ye W, Kim Y, Cotton S, Buchanan AS, . . . Joshi S. A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication. The Journal of Headache and Pain 2020; 21(1): Doi:10.1186/s10194-020-01110-9 DOI: https://doi.org/10.1186/s10194-020-01110-9

Ho TW, Edvinsson L and Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nature Reviews Neurology 2010; 6(10): 573-582 Doi:10.1038/nrneurol.2010.127 DOI: https://doi.org/10.1038/nrneurol.2010.127

Olesen J. Preface to the Second Edition. Cephalalgia 2016; 24(1_suppl): 9-10 Doi:10.1111/j.1468-2982.2003.00824.x DOI: https://doi.org/10.1111/j.1468-2982.2003.00824.x

Ashina M, Saper J, Cady R, Schaeffler BA, Biondi DM, Hirman J, . . . Smith J. Eptinezumab in episodic migraine: A randomized, double-blind, placebo-controlled study (PROMISE-1). Cephalalgia 2020; 40(3): 241-254 Doi:10.1177/0333102420905132 DOI: https://doi.org/10.1177/0333102420905132

Martelletti P, Schwedt TJ, Lanteri-Minet M, Quintana R, Carboni V, Diener H-C, . . . Vo P. My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed. The Journal of Headache and Pain 2018; 19(1): Doi:10.1186/s10194-018-0946-z DOI: https://doi.org/10.1186/s10194-018-0946-z

Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C and Akerman S. Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiological Reviews 2017; 97(2): 553-622 Doi:10.1152/physrev.00034.2015 DOI: https://doi.org/10.1152/physrev.00034.2015

Dodick DW. A Phase-by-Phase Review of Migraine Pathophysiology. Headache: The Journal of Head and Face Pain 2018; 58(4-16 Doi:10.1111/head.13300 DOI: https://doi.org/10.1111/head.13300

Lipton RB, Stewart WF, Diamond S, Diamond ML and Reed M. Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II. Headache: The Journal of Head and Face Pain 2001; 41(7): 646-657 Doi:10.1046/j.1526-4610.2001.041007646.x DOI: https://doi.org/10.1046/j.1526-4610.2001.041007646.x

Raffaelli B, Neeb L and Reuter U. Monoclonal antibodies for the prevention of migraine. Expert Opinion on Biological Therapy 2019; 19(12): 1307-1317 Doi:10.1080/14712598.2019.1671350 DOI: https://doi.org/10.1080/14712598.2019.1671350

Loder EW and Rizzoli P. Tolerance and Loss of Beneficial Effect During Migraine Prophylaxis: Clinical Considerations. Headache: The Journal of Head and Face Pain 2011; 51(8): 1336-1345 Doi:10.1111/j.1526-4610.2011.01986.x DOI: https://doi.org/10.1111/j.1526-4610.2011.01986.x

Lipton RB, Munjal S, Buse DC, Alam A, Fanning KM, Reed ML, . . . Dodick DW. Unmet Acute Treatment Needs From the 2017 Migraine in America Symptoms and Treatment Study. Headache: The Journal of Head and Face Pain 2019; 59(8): 1310-1323 Doi:10.1111/head.13588 DOI: https://doi.org/10.1111/head.13588

Tepper SJ. History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment. Headache: The Journal of Head and Face Pain 2018; 58(238-275 Doi:10.1111/head.13379 DOI: https://doi.org/10.1111/head.13379

Henson B, Hollingsworth H, Nevois E and Herndon C. Calcitonin Gene-Related Peptide (CGRP) Antagonists and Their Use in Migraines. Journal of Pain & Palliative Care Pharmacotherapy 2019; 34(1): 22-31 Doi:10.1080/15360288.2019.1690616 DOI: https://doi.org/10.1080/15360288.2019.1690616

Downloads

Published

2023-06-30

How to Cite

1.
Farenzena N, Fröhlich AC. Evaluation of the use of CGRP monoclonal antibodies (mAbs) in migraine prophylaxis in a private clinic. Headache Med [Internet]. 2023 Jun. 30 [cited 2024 Nov. 21];14(2):83-8. Available from: https://headachemedicine.com.br/index.php/hm/article/view/747

Issue

Section

Original

Similar Articles

You may also start an advanced similarity search for this article.