Cerebrospinal fluid (CSF) and idiopatic intracranial hypertension (IIH): a critical review

Authors

DOI:

https://doi.org/10.48208/HeadacheMed.2022.16

Keywords:

Headache, Pseudotumor cerebri, Idiopathic intracranial hypertension, Cerebrospinal fluid, Glymphatic system

Abstract

Pseudotumor cerebri is a syndrome that results from increased intracranial pressure. The main symptoms are headache, vision disturbances, and pulsatile tinnitus. Definitive diagnosis requires the presence of clinical and/or radiological signs of intracranial hypertension, high opening pressure on lumbar puncture (LP), and normal CSF constitution. Several studies have evaluated new contributions of CSF in the clinical evaluation and the in understanding of the pathophysiology of pseudotumor cerebri. Such studies have included the analysis of inflammatory biomarkers, adipokines, proteomic analysis, and CSF flow studies. In this review, we present the main results obtained so far and critically discuss the present status and the potential role of research involving the CSF in this condition. Based on current knowledge, it is possible to conclude that CSF research with new biomarkers has not yet provided information that can be employed in clinical practice at this moment. However, a better understanding of the constitution and dynamics of CSF circulation in patients with pseudotumor cerebri has brought some information about this condition and can potentially improve our knowledge about this condition in the future.

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2022-10-01

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1.
Domingues R, Vega M, Brunale F, Giafferi C, Senne C. Cerebrospinal fluid (CSF) and idiopatic intracranial hypertension (IIH): a critical review. Headache Med [Internet]. 2022 Oct. 1 [cited 2024 Dec. 26];13(3):167-73. Available from: https://headachemedicine.com.br/index.php/hm/article/view/649

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Vol. 13 No. 3 (2022)

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Review

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Copyright (c) 2022 Renan Domingues, Márcio Vega, Fernando Brunale, Carlos Giafferi, Carlos Senne

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