Fibromyalgia in patients with migraine: A literature review in the last 20 years




Migraine, Fibromyalgia, Fibromigraine, Quality of life


Possibly fibromyalgia and migraine share similar pathophysiological mechanisms, generating
an imbalance of neurotransmitters involved in pain modulation, with increased neuronal excitability. The association between these two conditions is frequent, increasing the disability of both.
We aimed to review articles published in the last 20 years about the presence of fibromyalgia
in patients with migraine and to analyze the quality of life of these patients.
Based on a literature search in the major medical databases and using the descriptors “migraine” and “fibromyalgia” we include articles published between 2001 and 2021. We found 387 articles, but only five met the inclusion criteria.
In five articles analyzed, 429 patients with migraine were found, in which fibromyalgia
was present in 31.5% of them, predominantly in women (p<0.0001). In this association, there was a higher risk for depression and worse quality of life.
The association of fibromyalgia in patients with migraine is frequent, increasing the disability
of these two diseases and generating great social impact. Knowledge of this association and the management of its consequences are necessary in medical practice.


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How to Cite

Fortes YML, Souza WP de O, Silva-Néto RP. Fibromyalgia in patients with migraine: A literature review in the last 20 years. Headache Med [Internet]. 2022 Jan. 25 [cited 2024 May 28];12(4):273-7. Available from:




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