Most prevalent symptoms associated with headache in COVID-19 patients in the acute phase: a systematic review

Authors

DOI:

https://doi.org/10.48208/HeadacheMed.2021.20

Keywords:

Headache, COVID-19, Coronavirus, Nervous system diseases, Anosmia, Ageusia

Abstract

Introduction
Considering the frequency of headache among the neurological symptoms of COVID-19, there is a need to understand other manifestations associated with this complaint.
Objective
To review the literature regarding the most prevalent symptoms associated with headache in patients diagnosed with COVID-19.
Method
A systematic literature review was carried out on studies that evaluated published articles about clinical characteristics and headache associated symptoms in patients diagnosed with COVID-19.
Results
Among the 1,190 patients in the analyzed studies, the following signs and symptoms were associated with headache: fever, hyposmia, anosmia, ageusia, phonophobia, dehydration, prostration and symptoms of the gastrointestinal tract.
Conclusion
Headache was the main neurological symptom of COVID-19, among the main associated symptoms are fever, hyposmia or anosmia, ageusia and phonophobia.

Downloads

Download data is not yet available.

References

Xavier AR, Silva JS, Almeida JPC, Conceição JFF, Lacerda GS and Kanaan S. COVID-19: clinical and laboratory manifestations in novel coronavirus infection. J Bras Patol Med Lab 2020; 56(1-9 Doi:10.5935/1676-2444.20200049 DOI: https://doi.org/10.5935/1676-2444.20200049

Painel Coronavírus. 2021: https://covid.saude.gov.br/

WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. 2021:

Magdy R, Hussein M, Ragaie C, Abdel-Hamid HM, Khallaf A, Rizk HI and Dahshan A. Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross

sectional study. Cephalalgia 2020; 40(13):1422-1431 Doi:10.1177/0333102420965140 DOI: https://doi.org/10.1177/0333102420965140

Wu Z and McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center

for Disease Control and Prevention. Jama 2020; 323(13):1239-1242 Doi:10.1001/jama.2020.2648 DOI: https://doi.org/10.1001/jama.2020.2648

Uygun Ö, Ertaş M, Ekizoğlu E, Bolay H, Özge A, Kocasoy Orhan E, . . .Baykan B. Headache characteristics in COVID-19 pandemic-a survey study. J Headache Pain 2020; 21(1):121 Doi:10.1186/s10194-020-01188-1 DOI: https://doi.org/10.1186/s10194-020-01188-1

Toptan T, Aktan Ç, Başarı A and Bolay H. Case Series of Headache Characteristics in COVID-19: Headache Can Be an Isolated Symptom. Headache 2020; 60(8):1788-1792 Doi:10.1111/head.13940 DOI: https://doi.org/10.1111/head.13940

Bolay H, Gül A and Baykan B. COVID-19 is a Real Headache! Headache 2020; 60(7):1415-1421 Doi:10.1111/head.13856 DOI: https://doi.org/10.1111/head.13856

Rocha-Filho PAS and Magalhães JE. Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia. Cephalalgia 2020; 40(13):1443-1451 Doi:10.1177/0333102420966770 DOI: https://doi.org/10.1177/0333102420966770

Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, . . .Yang Y. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut 2020; 69(6):1002-1009 Doi:10.1136/gutjnl-2020-320926 DOI: https://doi.org/10.1136/gutjnl-2020-320926

Caronna E, Ballvé A, Llauradó A, Gallardo VJ, Ariton DM, LallanaS,...Pozo-RosichP. Headache: Astrikingprodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia 2020; 40(13):1410-1421 Doi:10.1177/0333102420965157 DOI: https://doi.org/10.1177/0333102420965157

Umakanthan S, Sahu P, Ranade AV, Bukelo MM, Rao JS, Abrahao-Machado LF, . . .Kv D. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med J 2020; 96(1142):753-758 Doi:10.1136/postgradmedj-2020-138234

Anjos Paula RC, Maria Frota Vasconcelos T, Costa FBS, Brito LA, Torres DM, Moura AEF, . . .Sobreira-Neto MA. Characterization of Headache in COVID-19: a Retrospective Multicenter Study. Mol Neurobiol 2021; 58(9):4487-4494 Doi:10.1007/s12035-021-02430-w 14. Membrilla JA, de Lorenzo Í, Sastre M and Díaz de Terán J. Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross-Sectional Study. Headache 2020; 60(10):2176-2191 Doi:10.1111/head.13967 DOI: https://doi.org/10.1111/head.13967

Trigo J, García-Azorín D, Planchuelo-Gómez Á, Martínez-Pías E, Talavera B, Hernández-Pérez I, . . .Guerrero Á L. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study. J Headache Pain 2020; 21(1):94 Doi:10.1186/s10194-020-01165-8 DOI: https://doi.org/10.1186/s10194-020-01165-8

Downloads

Published

2021-10-17

How to Cite

1.
Salomão VR, Baccarin AJR, Okido TY. Most prevalent symptoms associated with headache in COVID-19 patients in the acute phase: a systematic review. Headache Med [Internet]. 2021 Oct. 17 [cited 2024 Dec. 22];12(2):105-9. Available from: https://headachemedicine.com.br/index.php/hm/article/view/456

Issue

Section

Review