Most prevalent symptoms associated with headache in COVID-19 patients in the acute phase: a systematic review




Headache, COVID-19, Coronavirus, Nervous system diseases, Anosmia, Ageusia


Considering the frequency of headache among the neurological symptoms of COVID-19, there is a need to understand other manifestations associated with this complaint.
To review the literature regarding the most prevalent symptoms associated with headache in patients diagnosed with COVID-19.
A systematic literature review was carried out on studies that evaluated published articles about clinical characteristics and headache associated symptoms in patients diagnosed with COVID-19.
Among the 1,190 patients in the analyzed studies, the following signs and symptoms were associated with headache: fever, hyposmia, anosmia, ageusia, phonophobia, dehydration, prostration and symptoms of the gastrointestinal tract.
Headache was the main neurological symptom of COVID-19, among the main associated symptoms are fever, hyposmia or anosmia, ageusia and phonophobia.


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How to Cite

Salomão VR, Baccarin AJR, Okido TY. Most prevalent symptoms associated with headache in COVID-19 patients in the acute phase: a systematic review. Headache Med [Internet]. 2021 Oct. 17 [cited 2024 Jun. 17];12(2):105-9. Available from: