Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis

Authors

  • Arão Belitardo Oliveira Universidade Federal de São Paulo
  • Bruna Visniauskas Tulane University School of Medicine
  • Jair Ribeiro Chagas Universidade Federal de São Paulo
  • Mario Fernando Prieto Peres Universidade de São Paulo

DOI:

https://doi.org/10.48208/HeadacheMed.2020.5

Keywords:

Physical Activity, Exercise Therapy, Angiotensin-Converting Enzyme, Chronic Pain, Headaches Disorders, Migraine, Sleep

Abstract

Angiotensin converting enzyme-1 (ACE) has been implicated in sleep regulation and nociception. In a secondary, per-protocol analysis, we investigated the effect of a 12-week aerobic exercise program on plasma ACE activity (primary outcome variable), migraine clinical outcomes, and psychometric scores between migraine and control, non-headache participants. Fifty-nine participants (migraine: n=31 and control: n=28) gave signed consent form and were per-protocol analyzed. At baseline, there were no differences between groups for ACE activity. After the intervention period, the ACE activity increased in the migraine exercise group compared to control waitlist group [mean difference (95% CI) = 33.8 nM.min– 1.mg–1 (1.0, 66.5), p = 0.02]. Among patients, the migraine exercise group showed greater numeric reduction in the number of sleep deprivation-triggered attacks compared to migraine waitlist group (-21 vs -8, respectively), and lower insomnia scores [mean difference (95% CI) = -0.625 (-996, -254), p = 0.001]. There was an inverse correlation between BECK-II insomnia domain scores and ACE activity (r = -0.53, p = 0.035). This study suggests that aerobic exercise training increases plasma ACE activity with possible implication on sleep regulation in migraine patients.

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Author Biographies

Arão Belitardo Oliveira, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Neurologia e Neurocirurgia - São Paulo - SP - Brasil.

Hospital Israelita Alber Einstein, Instituto do Cerebro - São Paulo - SP - Brasil.

Bruna Visniauskas, Tulane University School of Medicine

Tulane University School of Medicine, Department of Physiology - New Orleans - Louisiana - Estados Unidos.

Jair Ribeiro Chagas, Universidade Federal de São Paulo

Universidade Federal de São Paulo, Biologia Molecular - São Paulo - SP - Brasil.

Mario Fernando Prieto Peres, Universidade de São Paulo

Hospital Israelita Alber Einstein, Instituto do Cerebro - São Paulo - SP - Brasil.

Universidade de São Paulo, Instituto de Psiquiatria - São Paulo - SP - Brasil.

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Published

31/03/2020

How to Cite

1.
Oliveira AB, Visniauskas B, Chagas JR, Peres MFP. Plasma ACE activity after aerobic exercise training is related to sleep in migraine patients: A secondary, per protocol analysis. HM [Internet]. 2020 Mar. 31 [cited 2021 Oct. 24];11(1):14-21. Available from: https://headachemedicine.com.br/index.php/hm/article/view/13

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Section

Original

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