The diverse use of cannabis derivatives in the treatment of chronic pain

Authors

DOI:

https://doi.org/10.48208/HeadacheMed.2024.16

Keywords:

Medicinal cannabis, Cannabidiol, THC, Chronic pain

Abstract

Introduction
Chronic pain is a pathology that affects thousands of people annually, resulting from different factors and having different etiologies. Several treatments are available today for it, but some cases are still refractory.
Objective
This article seeks to highlight the impacts of using cannabis derivatives as an alternative in the treatment of chronic pain.
Methodology
This is a bibliographic review that used the PubMed and Scopus databases to search for and select articles on the use of cannabis derivatives in the treatment of chronic pain. Only clinical trials, cohort studies, case-control studies, and case reports were selected.
Results
336 articles were found, after applying the inclusion and exclusion criteria, 7 articles were selected to be analyzed, of which 3 used vaporized formulations, 3 used compounds for oral ingestion and 1 analyzed topical use.
Conclusion
Good efficiency was observed in the use of cannabis derivatives in the treatment of chronic pain, especially compounds rich in delta-9-tetrahydrocannabidiol (THC).

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References

Ascenção MD, Lustosa VR, Silva LJ. Canabinoides no tratamento da dor crônica. Rev Med Saude Brasilia. 2016;5(3):255-63.

Dellaroza MSG, Furuya RK, Cabrera MAS, Matsuo T, Trelha C, Yamada KN, Pacola L. Caracterização da dor crônica e métodos analgésicos utilizados por idosos da comunidade. Rev Assoc Med Bras. 2008;54(1):36-41. Doi: https://doi.org/10.1590/S0104-42302008000100018 DOI: https://doi.org/10.1590/S0104-42302008000100018

Varandas CMB. Fisiopatologia da dor [tese de mestrado]. Porto: Universidade Fernando Pessoa; 2013. 79 p.

Posso IP, Palmeira CCA, Vieira EBM. Epidemiology of neuropathic pain. Ver Dor. 2016;17(Suppl 1):S11-4. Doi: https://doi.org/10.5935/1806-0013.20160039 DOI: https://doi.org/10.5935/1806-0013.20160039

Kreling MCGD, Cruz DALM, Pimenta CAM. Prevalência de dor crônica em adultos. Rev Bras Enferm. 2006;59(4):509-13. Doi: https://doi.org/10.1590/S0034-71672006000400007 DOI: https://doi.org/10.1590/S0034-71672006000400007

Bonfá L, Vinagre RCO, Figueiredo NV. Uso de canabinoides na dor crônica e em cuidados paliativos. Rev Bras Anestesiol. 2008;58(3):267-79. Doi: https://doi.org/10.1590/S0034-70942008000300010 DOI: https://doi.org/10.1590/S0034-70942008000300010

Kim PS, Fishman MA. Cannabis for pain and headaches: primer. Curr Pain Headache Rep. 2017;21(19). Doi: https://doi.org/10.1007/s11916-017-0619-7 DOI: https://doi.org/10.1007/s11916-017-0619-7

Zurdi AW. História da cannabis como medicamento: uma revisão. Rev Bras Psiquiatr. 2006;28(2):153-7. Doi: https://doi.org/10.1590/S1516-44462006000200015 DOI: https://doi.org/10.1590/S1516-44462006000200015

Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly ME, Connett JE, Gupta K. Effect of Inhaled Cannabis for Pain in Adults with Sickle Cell Disease A Randomized Clinical Trial. JAMA Network Open. 2020;3(7):e2010874. Doi: https://doi.org/10.1001/jamanetworkopen.2020.10874 DOI: https://doi.org/10.1001/jamanetworkopen.2020.10874

Almog S, Aharon-Peretz J, Vulsons S, Ogintz M, Abalia H, Lupo T, Hayon Y, Eisenberg E. The pharmacokinetics, efficacy, and safety of a novel selective-dose cannabis inhaler in patients with chronic pain: A randomized, double-blinded, placebo-controlled trial. Eur J Pain. 2020;24:1505–1516. Doi: https://doi.org/10.1002/ejp.1605 DOI: https://doi.org/10.1002/ejp.1605

Bebee B, Taylor DM, Bourke E, Pollack K, Foster L, Ching M, Wong A. The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain. The Medical Journal of Australia. 2021;214(8):370-275. Doi: https://doi.org/10.5694/mja2.51014 DOI: https://doi.org/10.5694/mja2.51014

Chaves C, Bittencourt PCT, Pelegrini A. Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pain Medicine. 2020;21(10):2212-2218. Doi: https://doi.org/10.1093/pm/pnaa303 DOI: https://doi.org/10.1093/pm/pnaa303

Van de Donk T, Niesters N, Kowal MA, Olofsen E, Dahan A, van Velzen M. An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. Pain. 2019;160:860-869. Doi: https://doi.org/10.1097/j.pain.0000000000001464 DOI: https://doi.org/10.1097/j.pain.0000000000001464

Palmieri B, Laurino C, Vadalà M. Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan). International Journal of Pharmacy Practice. 2019;27:264-270. Doi: https://doi.org/10.1111/ijpp.12514 DOI: https://doi.org/10.1111/ijpp.12514

Xu DH, Cullen BD, Tang M, Fang Y. The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. Current Pharmaceutical Biotechnology. 2020;21:000-000. Doi: https://doi.org/10.2174/1389201020666191202111534 DOI: https://doi.org/10.2174/13892010MTAykNjgm5

McDonagh MS, Morasco BJ, Wagner J, Ahmed AY, Fu R, Kansagara D, Chou R. Cannabis-Based Products for Chronic Pain: A Systematic Review. Annals of Internal Medicine. 2022;175(8). Doi: https://doi.org/10.7326/M21-4520 DOI: https://doi.org/10.7326/M21-4520

Lourenço JIV. Administração de Fármacos por Via Inalatória – Uma Via Promissora [master’s thesis]. Coimbra: Faculdade de Farmácia da Universidade de Coimbra, Universidade de Coimbra; 2014. 29 p.

Schinko FGB, Tavares TM, Santos MF. Cannabis: Past, present, and future. Seven Editora. 2024;2:695-703. Doi: https://doi.org/10.56238/sevened2024.003-051 DOI: https://doi.org/10.56238/sevened2024.003-051

Johal H, Devji T, Chang Y, Simone J, Vannabouathong C, Bhandari M. Cannabinoids in Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis. Clin Med Ins: Arthritis and Musculoskeletal Disord. 2020;13:1-13. Doi: https://doi.org/10.1177/1179544120906461 DOI: https://doi.org/10.1177/1179544120906461

Pantoja-Ruiz C, Restrepo-Jimenez P, Costañeda-Cardona C, Ferreirós A, Roselli D. Cannabis e dor: uma revisão de escopo. Brazilian Journal of Anesthesiology. 2022;72(1):142-151. Doi: https://doi.org/10.1016/j.bjane.2021.06.018 DOI: https://doi.org/10.1016/j.bjane.2021.06.018

Chou R, Ahmed AY, Morasco BJ, Bougastos C, Dana T, Fu R, Gilbreath T. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update. Comparative Effectiveness Review. 2023;(250) [internet]. DOI: https://doi.org/10.23970/AHRQEPCCER250UPDATE2023

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Published

2024-06-30

How to Cite

1.
Ferreira Marques LF, Dutra AL de A, Zafalon B, Fernandes E de BD, Pachá DP, Espíndola RS. The diverse use of cannabis derivatives in the treatment of chronic pain. Headache Med [Internet]. 2024 Jun. 30 [cited 2024 Dec. 4];15(2):72-7. Available from: https://headachemedicine.com.br/index.php/hm/article/view/1054

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Review