Prevalence of compulsion in migraine patients and its association with analgesics abuse




Migraine, Medication-overuse, Obsessive compulsive disorder (OCD)


Migraine, is one of the most prevalent types of headaches, affects around 15% of people world wide, more common among women, causes a great effect in the quality of life of the individual. With the purpose to ease phonophobia, photophobia, nausea followed by vomiting, unilateral, pulsatile and intense, headache crisis the patients have a drug overuse. The medication-overuse headache (MOH) is an emerging problem, due to the possibility of developing psychiatric disorders like obsessive compulsive disorder (OCD).
Determine a prevalence of OCD in migraine patients, evaluating different scopes of it, including the association or not with drug abuse.
A cross-sectional study with 117 patients of both sexes, older than 18 years old. Three questionnaires were used: Barratt Impulsiveness Scale (BIS-11); Obsessive Compulsive Inventory-Revised (OCI-R) and the Migraine Disability Assessment (MIDAS). The data collected was placed in an electronic worksheet and processed in Software SPSS Statistics 22.0. There was an assumption of a p value of 0,05 to all cases with the intention to reject the null hypothesis.
Findings suggest that individuals with a medication-overuse profile have a higher tendency to develop compulsive symptoms and the seriousness of the migraine symptoms is extremely related to medication-overuse headache.
The study showed that patients with medication-overuse headache have a higher tendency to develop compulsive behavior.


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Souza NE, Calumby ML, Afonso EDO, Zannon T, Nogueira S, Beatriz A, et al. Cefaleia : migrânea e qualidade de vida. Rev de Saúde. 2015;23–6. DOI:

Padovan M, Ferreira A. Enxaqueca é incluída pela OMS no rol de doenças mais incapacitantes [Internet]. Correio Braziliense. 2018 [cited 2020 Jul 8]. Available from:,653392/enxaqueca-e-incluida-pela-oms-no-rol-de-doencas-mais-incapacitantes.shtml

Carezzato NL, Hortense P. Migraine: etiology, risk, triggering, aggravating factors and clinical manifestations. Rev da Rede Enferm do Nord. 2014;15(2):334–42. doi: 10.15253/2175-6783.2014000200019 DOI:

Olesen J. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3 ed. Cephalalgia. 2018;38(1):1–211. doi: 10.1177/0333102417738202. DOI:

Speciali JG, Dach F, Setlin R, Ferreira K. Ano mundial contra a dor de cabeça. International Association for the Study of Pain. 2011;3.

Moreira de Barros GA, Calonego MAM, Mendes RF, Castro RAM, Faria JFG, Trivellato SA, et al. The use of analgesics and risk of self‐medication in an urban population sample: cross‐sectional study. Brazilian J Anesthesiol. 2019;69(6):529–36. DOI:

Tavares H, Alarcão G. Manual Clínico Dos Transtornos Do Controle Dos Impulsos. 1. ed. Porto Alegre: Artmed; 2008. 19–36.

Conceição M. Transtorno obsessivo - compulsivo obsessivo-. Rev Bras de Psiquiatr. 2000;22(Supl II):16–9. DOI:

Bobes J, García-Portilla MP, Bascarán MT, Sáiz PA, Bobes-Bascarán MT, Bousoño M. Quality of life in obsessive-compulsive disorder. Rev Psiquiatr Clin. 2007;35(1):293–303. DOI:

Torres AR, Lima MCP. Epidemiologia do transtorno obsessivo-compulsivo: uma revisão. Rev Bras Psiquiatr. 2005;27(3):237–42. DOI:

Malloy-Diniz LF, Mattos P, Leite WB, Abreu N, Coutinho G, De Paula JJ, et al. Tradução e adaptação cultural da Barratt Impulsiveness Scale (BIS-11) para aplicação em adultos brasileiros. J Bras Psiquiatr. 2010;59(2):99–105. doi:10.1590/S0047-20852010000200004 DOI:

Huppert JD, Walther MR, Hajcak G, Yadin E, Foa EB, Simpson HB, et al. The OCI-R: Validation of the subscales in a clinical sample. J Anxiety Disord. 2007;21(3):394–406. doi: 10.1016/j.janxdis.2006.05.006 DOI:

Foa EB, Huppert JD, Leiberg S, Langner R, Kichic R, Hajcak G, et al. The obsessive-compulsive inventory: Development and validation of a short version. Psychol Assess. 2002;14(4):485–96. doi:10.1037/1040-3590.14.4.485 DOI:

Fragoso YD. MIDAS (migraine disability assessment): A valuable tool for work-site identification of migraine in workers in Brazil. Sao Paulo Med J. 2002;120(4):118–21. doi:10.1590/S1516-31802002000400006 DOI:

Minen MT, Begasse De Dhaem O, Kroon Van Diest A, et al. Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry. 2016;87(7):741-749. doi:10.1136/jnnp-2015-312233. DOI:

D'Amico, D, Sansone, E, Grazzi, L, et al. Multimorbidity in patients with chronic migraine and medication overuse headache. Acta Neurol Scand. 2018; 138: 515– 522. doi:10.1111/ane.13014. DOI:

Radat F, Swendsen J. Psychiatric comorbidity in migraine: a review. Cephalalgia. 2005;25(3):165-178. doi:10.1111/j.1468-2982.2004.00839.x DOI:

Cabral A, Tolentino A, Paula CBDE, Santos LM. Prevalência de impulsividade em migranosos sem e com abuso de analgésico. Arq Neuropsiquiatr. 2019;778–82. doi:10.1590/0004-282X20200071 DOI:




How to Cite

Braz ACM, Filho JCCP, Barros MCL de, Ribeiro MHV, Sousa MS, Santos VH dos, Silva DJ, Jurno ME. Prevalence of compulsion in migraine patients and its association with analgesics abuse. Headache Med [Internet]. 2024 Jun. 29 [cited 2024 Jul. 14];15(2):92-7. Available from:




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