The role of TRPM8 in the pathophysiology of migraine

Autores

DOI:

https://doi.org/10.48208/HeadacheMed.2020.17

Palavras-chave:

TRPM Cation Channels, Migraine Disorders, Hyperalgesia

Resumo

The Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the mammal TRPM subfamily. TRPM8 is involved in menthol-induced cold allodynia, a condition that activates the left lateral thalamus and the primary and secondary somatosensory cortices, which are related to pain processing. Cold is a well-known trigger of migraine. Thirty-nine articles were identified, 27 of which were selected for review after reading the abstracts. Fourteen papers were further excluded. TRPM8 seems to be involved in the pain mechanism of migraine and therefore should be considered as a target for the development of therapies against this type of primary headache.

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Publicado

2020-09-30

Edição

v. 11 n. 3 (2020)

Seção

Revisões

Licença

Copyright (c) 2020 Headache Medicine

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Como Citar

1.
The role of TRPM8 in the pathophysiology of migraine. Headache Med [Internet]. 30º de setembro de 2020 [citado 22º de janeiro de 2026];11(3):57-60. Disponível em: https://headachemedicine.com.br/hm/article/view/329