Changes in cerebrospinal fluid in patients with fibromyalgia

Abstract

Fibromyalgia is a chronic disorder with unknown etiology and pain is the main characteristic. Cerebrospinal fluid levels of neurotransmitters and neuropeptides can give information about the neuronal activity of central nervous system in patients with fibromyalgia. The objective of this research is to review the main alterations of neurotransmitters and neuropeptides in cerebrospinal fluid in patients with fibromyalgia. ScieLo, Lilacs and PubMed databases were searched, without year limitation, in Portuguese, English and Spanish idioms, using the keywords "fibromyalgia" and "cerebrospinal fluid". 120 studies were found and, after analysis, 14 were included in this research. Some substances were relates to fibromyalgia, which is in agreement with some researches that define fibromyalgia as a central nervous system disorder.