Orexin-A CSF levels correlate with anxiety but not excessive daytime sleepiness in chronic migraine

Authors

  • Mario Fernando Prieto Peres
  • Domingos Savio Vieira
  • Marcelo Rodrigues Masruha
  • André Leite Gonçalves
  • Juliane Prieto Peres Mercante
  • Maria da Graça Naffah-Mazzacoratti

DOI:

https://doi.org/10.48208/HeadacheMed.2011.9

Keywords:

Migraine, Anxiety, Orexin

Abstract

Background: The hypothalamus is a key brain region in the control of energy metabolism, sleep and circadian rhythms, stress and anxiety, food intake, sexual and reproductive behaviors. Orexin-A (hypocretin-1) is a neuropeptide, synthesized in the hypothalamus extensively linked to sleep/wake states, particularly excessive daytime sleepiness. Chronic migraine is comorbid with several conditions but little is known about its mechanisms. We aimed to study the role of orexin-A in the mechanism of chronic migraine and comorbid conditions. Methods: We studied orexin-A levels in the CSF of 60 chronic migraine patients, comparing with age and sex matched controls, and comorbidity with anxiety, depression and excessive daytime sleepiness, using appropriate scales. Results: Orexin-A levels were inversively correlated with anxiety levels (r=-308, p=0,03), but not depression and excessive daytime sleepiness. Orexin levels in CM patients were not different than controls. Discussion/Conclusion: Anxiety in CM may be due to a decrease in orexin-A or may be the cause of its depletion. The orexinergic system may be implicated in anxiety comorbid with migraine.

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Author Biographies

Mario Fernando Prieto Peres

1 Instituto Israelita de Ensino e Pesquisa - Hospital Albert Einstein, Sao Paulo, Brazil

2 UNIFESP, Escola Paulista de Medicina, Department of Neurology, Sao Paulo, Brazil

3 FMABC, Department of Neurology, Sao Paulo, Brazil

Domingos Savio Vieira

Instituto Israelita de Ensino e Pesquisa - Hospital Albert Einstein, Sao Paulo, Brazil
UNIFESP, Escola Paulista de Medicina, Department of Neurology, Sao Paulo, Brazil

Marcelo Rodrigues Masruha

Instituto Israelita de Ensino e Pesquisa - Hospital Albert Einstein, Sao Paulo, Brazil

UNIFESP, Escola Paulista de Medicina, Department of Neurology, Sao Paulo, Brazil

André Leite Gonçalves

Instituto Israelita de Ensino e Pesquisa - Hospital Albert Einstein, Sao Paulo, Brazil

UNIFESP, Escola Paulista de Medicina, Department of Neurology, Sao Paulo, Brazil

FMABC, Department of Neurology, Sao Paulo, Brazil

Juliane Prieto Peres Mercante

Instituto Israelita de Ensino e Pesquisa - Hospital Albert Einstein, Sao Paulo, Brazil

Maria da Graça Naffah-Mazzacoratti

UNIFESP, Escola Paulista de Medicina, Department of Neurology, Sao Paulo, Brazil

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Published

30/06/2011

How to Cite

1.
Peres MFP, Vieira DS, Masruha MR, Gonçalves AL, Mercante JPP, Naffah-Mazzacoratti M da G. Orexin-A CSF levels correlate with anxiety but not excessive daytime sleepiness in chronic migraine. HM [Internet]. 2011 Jun. 30 [cited 2022 Jul. 7];2(2):41-5. Available from: https://headachemedicine.com.br/index.php/hm/article/view/77

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Original

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