Successful treatment of SUNCT syndrome with divalproex sodium extended-release

Abstract

Introduction: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome is a primary rare headache. This syndrome is known to be refractory to pharmacotherapy. Various treatments have been tried for SUNCT syndrome, generally of little benefit. Objective: To report a case of SUNCT syndrome who was successfully treated with divalproex sodium extended-release (DVPX ER) and to review the literature about of drugs used in this treatment. Patient and Method: The authors report a case of a 61 year-old man, suffering from SUNCT syndrome, who was successfully treated with DVPX ER. We review the literature about several categories of drugs that are used in the treatment to this syndrome. Conclusion: SUNCT syndrome is clinically well identified, but it is poorly treated. This is first report of SUNCT syndrome responsive to DVPX ER.