In humans, intrathecal injection of oxytocin is effective in treating low back pain for up to 5 hours.(28) Interestedly, it was described an enhanced hind paw withdrawal latency in response to nociceptive heat after OT subcutaneous administration in rat, an effect also found in the untreated cage mates of an OT-treated animal. This analgesic action of OT was canceled in OT-ANT-injected cage mates. Suggesting that cage mates develop anti-nociception mediated via olfactory tract, which is induced throw, an oxytocinergic mechanism.(29)
HEADACHE AND OXYTOCIN
Phillips and colleagues(30) reported that acute migraine headache attack can be relieved by intravenous oxytocin. On the other hand, a few authors reported that there is a lactational headache in the literature attributed to OT surges in association with the milk-ejection reflex.(31,32) A case of a 26-year-old woman suffering from brief attacks of headache that happened on every occasion of nursing was reported by Askmark and Lundberg.(32) However, a case was described when the apparent headache trigger was breast overfulness, and not the oxytocin surge, occurring when the infant was sleeping through the night or after a missed, delayed, or partial feed. In this case, interestingly, the headaches were alleviated by putting the baby to the breast (activation of the milk-ejection reflex).(33)
In conclusion, pain is a frequent complain observed in a neurological outpatient clinic. In this report, 51% of the patients complained of some type of pain, the more frequents were headache and carpal tunnel syndrome. Oxytocin plays a major role in the mechanism of pain regulation, particularly through the endogenous antinociceptive neuronal system.
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