Migraine and inflammation

Publicado na 3ª edição de 2009

The migraine attacks seem to be associated with inflammation. This inflammation process would be triggered by some peptides such as substance P and CGRP. Those peptides are released by free terminals of trigeminal nerve. However, little is known about the actual role of inflammation in the migraine pathogenesis. Some studies demonstrated increased levels of proinflammatory cytokines in serum and cerebrospinal fluid of patients with migraine, even during interictal periods. Also, several migraine comorbidities, such as depression, fibromyalgia, and isquemic stroke, are associated with increased proinflamatory cytokines as well. Therefore it is possible that there is a role of inflammation in the pathogenesis of migraine and in the susceptibility to pain attacks. One possible explanation is the association between inflammation and glutamate metabolism, since this neurotransmitter has been recognized as an important molecule in migraine pathogenesis. Several issues require further studies, such as the relationship between the severity of systemic inflammation and the length of migraine and the patient's age. The impact of prophylactic treatment of migraine on the inflammation is still unknown. The clarification of the role of inflammation in the migraine pathogenesis is one of the key issues for its better understanding.

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