Headache Medicine 2021, 12(3):270 p-ISSN 2178-7468, e-ISSN 2763-6178

270

ASAA

DOI: 10.48208/HeadacheMed.2021.42

Headache Medicine

Thesis

Oxytocin, vasopressin and nitric oxide levels in cerebrospinal uid

in women with migraine and bromyalgia (Abstract)

Níveis de ocitocina, vasopressina e óxido nítrico no líquido cefalorraquidiano em mulheres com enxaqueca e

bromialgia (Resumo)

Louana Cassiano da Silva Lima

Thesis (Doctorate in Neurosciences). Postgraduation in Neuropsychiatry and Behavioral Sciences. Federal University of Pernambuco, Recife, Brazil.

2017. 86 f. Supervisor: Prof. Dr. Marcelo Moraes Valença.

Introduction

Migraine and bromyalgia share similar pathophysiological mechanisms. Alterations in the nervous

system indicate the involvement of brain function in bromyalgia. Signicant changes in the plasma

concentrations of oxytocin, vasopressin, and nitric oxide in migraineurs have been reported.

Objective

To analyze the concentrations of oxytocin, vasopressin, and nitric oxide in the cerebrospinal uid

(CSF) of women with migraine and bromyalgia and correlate the levels with headache intensity,

headache impact, symptoms of depression and anxiety, stress levels, sleep quality, and fatigue.

Method

This is an observational cross-sectional study performed at the Hospital das Clínicas of the Federal

University of Pernambuco. For this, 246 women were interviewed. Headache characteristics in the last

three months were reported and classied according to ICHD-3β. American College of Rheumatology

criteria (2010) were used to classify bromyalgia. All women respond to questionnaires regarding

depressive and anxious symptomatology, fatigue severity, perception of stress, quality of sleep, and

headache impact. CSF sample was collected from 33 women and analyzed by the radioimmunoassay

technique.

Results

There was no relationship between oxytocin, vasopressin, and nitric oxide levels in the CSF in migraine

and bromyalgia patients. Relationships with headache intensity, headache impact test, depressive

and anxious symptoms, fatigue, stress, and sleep quality were not established. In women with

migraine, the presence of bromyalgia syndrome increases the pain intensity of headache (migraine

7.95 ± 0.12 vs. migraine + bromyalgia 8.78 ± 0.21, p <0.05), the impact of headache (migraine

63.88 ± 0.67 vs. migraine + bromyalgia 67.73 ± 1.25, p <0.05), depressive symptomatology

(migraine 6.45 ± 0.38 vs. migraine + bromyalgia 8.9 ± 0.38, p <0.05) and the perceived stress

(migraine 26.6 ± 0.63 vs. migraine + bromyalgia 30.73 ± 0.99, p <0.05).

Conclusion

No correlation was found between oxytocin, vasopressin, and nitric oxide levels in women with

migraine and bromyalgia.

louana_cs@hotmail.com

Received: November 15, 2021

Accepted: December 29,2021

Keywords:

Migraine disorders,

Fibromyalgia

Cerebrospinal uid

Nitric oxide

Oxytocin

Vasopressins

Depression, Anxiety

Stress

Psychological