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218 Headache Medicine, v.2, n.4, p. 218, Oct./Nov./Dec. 2011
Oculo-nasal autonomic symptoms in migraine and cluster
headache (Abstract)
Sinais and sintomas autonônomicos óculo-nasais na migrânea e na cefaleia em
salvas (Resumo)
Maria da Conceição Filgueira Sampaio
Universidade Federal de Pernambuco. Pós-graduação em Neuropsiquiatria e Ciências do Comportamento
(área de concentração: Neurociências). PhD Thesis. 2010.
Orientadores: Marcelo Moraes Valença/Wilson Farias da Silva
Sampaio MCF. Oculo-nasal autonomic symptoms in migraine and cluster headache (Abstract).
Headache Medicine. 2011; 2(4):218
Migraine is a primary, incapacitating headache.
Autonomic symptoms may occur during migraine crises, but
are rarely mentioned in the literature. The aim of this study
was to determine the frequency of autonomic symptoms during
migraine crises. A series of case studies were used, data were
collected from both the private patient records and from the
headache clinic of the Clinical Hospital (HC) of the Federal
University of Pernambuco (UFPE) from July 2005 to July 2008.
Patients who had headaches specifically diagnosed as
migraine, with or without aura, were selected, in accordance
with criteria established by the International Headache Society.
The research was approved by the Ethics Committee of CCS-
UFPE and the results analyzed with SPSS 15.0. Six-hundred-
eight patients were selected, 266 (39.8%) of whom showed
autonomic symptoms as part of clinical signs of migraine crisis.
Of those, 125 had conjunctive hyperemia (102 women and
23 men), 110 had tearing (93 women and 17 men), 70 had
eyelid edema (63 women and 8 men), 21 had runny nose (18
women and 3 men), and 33 had nasal obstruction (25 women
and 8 men). With respect to the laterality of the pain, 309
(46.3%) were unilateral, 160 (24.0%) bilateral and 45 (6.7%)
unibilateral. 87 (13.0%) had unilateral and/or bilateral pain,
8 (1.2%) had unilateral and/or unibilateral, and 1 (0.2%)
had unilateral and/or bilateral and /or unibilateral. Aura were
found in 126 (18.9%) of the 667 examined. The most frequent
triggering factor was stress (emotional), 263 (47.5%) out of
554. 165 (29.8%) were triggered by sleep disturbance, 56
(10.1%) by fasting, 13 (2.3%) by strong smells, 15 (2.7%) by
eating chocolate, 9 (1.6%) by drinking an alcoholic beverage,
1 (0.2%) by physical effort, 9 (1.6%) from eating fried foods,
23 (4.2%) could not specify what the trigger was, and 114
(17.1%) did not supply this information. 405 (60.7%) of the
667 had a family history of migraines. The results of this
research indicate that although autonomic symptoms are
usually found in cases of unilateral pain, they may also be
found in patients with bilateral pain. As to autonomic symptoms
in the case of unilateral pain, eye disturbances (tearing,
conjunctive hyperemia and eyelid edema) were more common
than nasal (runny nose, nasal obstruction). No statistically
Correspondence
Maria da Conceição Filgueira SampaioMaria da Conceição Filgueira Sampaio
Maria da Conceição Filgueira SampaioMaria da Conceição Filgueira Sampaio
Maria da Conceição Filgueira Sampaio
concei2000@uol.com.br
significant relation was found between autonomic symptoms
and unilateral pain, nor was autonomic symptoms related to
the severity of the headaches. Aura, gender, triggering factors
and family history did not show any relationship to the
appearance of autonomic symptoms.
THESIS