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Headache Medicine
ISSN 2178-7468
e
-ISSN 2763-6178
v.11
Supplement
p. 22
October 2020.
22
ASAA
DOI: 10.48208/HeadacheMed.2020.Supplement.22
Ferreira, F. M.; Dantas, M. I.; Pereira, T.; Feitosa, A. Santos, I.; Rodrigues, I. K.; DeSantana, J.
Headache Medicine
Pacientes com migrânea crônica apresentam sintomas depressivos e má
qualidade de vida relacionada à saúde: estudo observacional caso-controle
Fernanda Mylla Ferreira, Maria Ivone Dantas, Thaís Pereira, Amanda Feitosa, Itanara dos Santos, Ingrid Kyelli Rodrigues,
Josimari DeSantana
Universidade Federal de Sergipe
Introdução
Enxaqueca é uma condição clínica crônica, geralmente associada a comorbidades, como ansiedade, depressão e síndrome do pânico,
além de possuir um fardo considerável na qualidade de vida. Os objetivos deste estudo foram mensurar a presença de sintomas de
ansiedade e depressão e avaliar os aspectos relacionados à qualidade de vida e qualidade do sono entre migranosos crônicos e
indivíduos saudáveis.
Material e Métodos
Trata-se de um estudo observacional do tipo caso-controle, realizado com migranosos crônicos e indivíduos saudáveis com idade entre
18 e 50 anos. Foram seguidas as recomendações para comunicação de estudos observacionais (STROBE). O estudo foi aprovado pelo
Comitê de Ética e Pesquisa da Universidade Federal de Sergipe (CAEE: 08310319.1.0000.5546). A amostragem foi por conveniência,
no período entre janeiro de 2019 e fevereiro de 2020. Foram mensuradas as seguintes variáveis: ansiedade (Escala Hospitalar de
Ansiedade e Depressão -HAD), qualidade ede vida (Medical Outcomes Study 36 – Item Short Form Health Survey SF-36) e qualidade
de sono (Índice de Qualidade do Sono de Pittsburgh - PSQI). O software utilizado para análises estatísticas foi o GraphPad Prism versão
6.0 (San Diego, CA, USA). O teste de Shapiro-Wilk foi utilizado para analisar a normalidade (dados paramétricos - teste t para medidas
independentes e dados não paramétricos - teste Mann-Whitney), com p signicativo <0,05).
Resultados
A amostra foi constituída por 32 pacientes com enxaqueca (GE) e 22 voluntários no grupo controle saudável (GC). Os sintomas de
ansiedade mensurados através da HAD não apresentaram diferença entre GE e GC (p=0,418). Porém, o grupo GE apresentou maior
presença de sintomas depressivos que GC (p=0,016). Os aspectos gerais relacionados à qualidade de vida foram signicativamente
piores no GE (52,43±2,65, de 0-100) que no GC (75,91±2,68, de 0-100) (p<0,001) no escore total. Ao realizar uma análise por
domínios, os migranosos apresentaram escores signicativamente piores nos oito domínios do que indivíduos controle. A qualidade do
sono avaliada por meio dos escores do PSQI não diferiu entre GE (10,44±0,63, de 0-21) e GC (8,95±0,84, de 0-21) (p=0,161).
Conclusão
Pacientes com migrânea crônica apresentam sintomas de depressão e má qualidade de vida relacionada a saúde.
Descritores:
Qualidade de vida, Ansiedade, Depressão, Qualidade do sono, Migrânea crônica