Pesquisa no site: 'central nervous system'


The use of antiepileptic drugs in migraine prophylaxis. Why just some of them?

Introduction: Migraine is the most frequent manifestation of primary headaches. It is characterized by the recurrence of episodes which can last from 4 to 72 hours. Although it is a chronic recurrent disease, the number of episodes/month (?2) and the severity of its impact on the pa...


The role of caffeine in the headaches: Attenuating or aggravating factor?

Introduction: Caffeine is often used in the treatment of headaches, either on its own or with other medications. Its constrictor effect in cerebral vessels is well known, but the extent to which it aggravates or improves other mechanisms is still unknown. Objectives


Headache and Neuroimmunology: controversies

Headaches are prevalent among patients with neuroimmunological disorders of the central nervous system (CNS). Some autoimmune diseases of the CNS are traditionally recognized as headache causes and therefore are included in the International Headache Disorders Classification. In other conditions, su...


Melatonin in headache disorders

Melatonin have diverse physiological functions, including the control of circadian rhythms, sleep regulation, enhancement of immunological functioning, free radical scavenging and antioxidant effects, inhibition of oncogenesis, mood regulation, vasoregulation, regulation of seasonal reproductive act...


Alterações no líquido cefalorraquidiano em pacientes com fibromialgia

Fibromyalgia is a chronic disorder with unknown etiology and pain is the main characteristic. Cerebrospinal fluid levels of neurotransmitters and neuropeptides can give information about the neuronal activity of central nervous system in patients with fibromyalgia. The objective of this research...


Primary headaches and myofascial pain syndrome

Myofascial pain syndrome is a complex of sensory, motor and autonomic symptoms that are caused by myofascial trigger points. Compression of these trigger points can induce local and referred pain. This article reviews the available published knowledge about the relationship of primary headaches and ...


Melatonina reverte a expressão de CGRP induzida pela capsaicina


Introdução: CGRP, um peptídeo produzido e liberado no sistema nervoso central e potente vasodilatador, tem sido implicado na fisiopatologia da Migrânea. Devido a isso, tem surgido diversas terapias direcionadas ao CGRP que reduzem seus n&i...